Science (April 20, 2011)
In the future, when you enter the doctor's office or hospital, you can ask not only about your allergies and blood, but also about your gut type. Scientists from the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and employees of an international consortium MetaHIT, found that people have three different types of gut. The study, published in Nature
, and reveals microbial genetic markers associated with traits as an indicator of age, sex and body weight. These bacterial genes one day be used for diagnosis and prediction of diseases such as colorectal cancer, and information about the intestinal type of person could inform treatment. We all have bacteria in our gut that help digest food, destroy toxins, produce some vitamins and essential amino acids, and form a barrier against invaders. But the composition of that microbial community - the relative number of different species of bacteria - varies from person to person. We found that a combination of microbes in the human intestine is not by chance, says Peer Bork, who led the research at EMBL: our intestinal flora may be located in three different types of community - three different ecosystems, if you want. Bork and his colleagues first used stool samples for analysis of intestinal bacteria with 39 people from three different continents (Europe, Asia and America), then expanded the study to additional 85 persons of Denmark and 154 from America. They found that these cases can be divided into three groups based on which species of bacteria occurred in large numbers in the gut: each person can say one of three types of cancer, or enterotypes. Scientists still do not know why people have different types of gut, but suggest that they may be related to differences in how their immune system distinguish between "friendly" and harmful bacteria, or different ways to release hydrogen waste cells. Like blood, the guts type does not depend on rice as an indicator of age, gender, ethnicity and body mass. But the researchers did find, for example, that elderly cancer appears to be more microbial genes involved in the destruction of carbohydrates than young people, perhaps because, as we age, we become less efficient at processing those nutrients, so To survive in the human intestinal tract, bacteria must take on the task. The fact that there are bacterial genes associated with traits such as age and weight indicates that may be markers for traits such as obesity and diseases such as colorectal cancer, Bork says that may have implications for diagnosis and prognosis. If this be so, in the diagnosis and evaluation of the probability of infection of the patient's specific disease, doctors can look for clues not only in the patient's body, but the bacteria that live in it. And after the diagnosis, treatment can be tailored to the type of cancer patient for best results. Recommend this story on Facebook, Twitter
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and Google +1: Other Bookmark and collaboration: History Source: above story is reprinted with provided through, services AAAS. Note: materials may be edited for content and length. For more information, please contact the source listed above. Journal Links Manimozhiyan Arumuham, Jeroen RAPN, Eric Pelletier, Denis Le Paslier, Takudzi Yamada, Daniel G. Mende, Gabriel R. Fernandez, Takeaway Julien, Thomas Bruls, Jean-Michel Butte Marcelo Bertalan, Natalia Borruel, Francesc Casellas, Leiden Fernandez Laurent Gautier, Torben Hansen, Masahira Hattori, Tetsuya Hayashi, Michiel Kleerebezem, Ken Kurokawa, Marion Leclerc, Florence Levenez, Chaysavanh Manichanh, H. Bjrn Nielsen, Trine Nielsen, Nicholas Ponce, Julie Pulen, Junjie Qin, Thomas Sicheritz-Ponten, Sebastian Timsit, David Torrents, Edhardo Ugarte, Erwin G. Zoetendal, Jun Wang, Francisco Guarner, Oluf Pedersen, M. Willem de Vos, Sren Brunak, Joel Dore, MetaHIT consortium, Jean Weissenbach, S. Dusko Ehrlich, Peer Bork, Mara Antoln , Francois Artiguenave, Herve M. Blottiere, Mathieu Almeida, Christian Brechot Carlos Curran, Christian Chervaux, Antonella Cultrone, Christine Delorme, Grard Denariaz, Rozenn Dervyn, Conrad strattera 10mg W. Foerstner, Carsten Friss, Maarten van de Guchte, Eric Guedon, Florence Haimet Wolfgang Huber, Johan van Hylckama-Vlieg, Zhame Alexander, Catherine Juste, Ghalia Kaci Jan Knol, Omar Lakhdari, Severin Layec, Karina Le Roux, Emmanuelle Maguin, Alexander Mrieux, Raquel Melo Minardi, Christine M'rini Jean Muller, Raish Oozeer, Julian Parkhill Pierre Renault, Maria Rescigno, Nicholas Sanchez, Shinichi Sunagawa Antonio Torrejon, Keith Turner, Gaetano Vandemeulebrouck, Encarna Varela, Johanan Vinogradsky, George Zeller. Enterotypes per person mikrobiomom intestine. Nature, 2011, DOI:
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